Peflotab is a synthetic, broad-spectrum fluoroquinolone antibiotic containing pefloxacin (as pefloxacin mesylate). It exerts a bactericidal effect by inhibiting bacterial DNA gyrase and topoisomerase IV, critical enzymes necessary for bacterial DNA replication, repair, and transcription. Peflotab exhibits excellent tissue penetration, high plasma concentrations, and a prolonged elimination half-life, making it effective against a broad array of Gram-negative and Gram-positive aerobic pathogens.
Primary Medical Indications
Peflotab is indicated for adults for the treatment of mild, moderate, and severe bacterial infections, including:
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Urinary Tract & Renal Infections: Severe uncomplicated and complicated cystitis, pyelonephritis, and prostatitis.
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Respiratory Infections: Acute exacerbations of chronic bronchitis, bronchopneumonia, and severe hospital-acquired lower respiratory infections.
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Gastrointestinal & Abdominal Infections: Typhoid fever (enteric fever), severe infectious diarrhea, peritonitis, and biliary tract infections.
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Skin, Soft Tissue & Bone Infections: Infected ulcers, wound infections, cellulitis, osteomyelitis, and septic arthritis.
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Systemic Infections: Bacterial septicemia and endocarditis caused by susceptible bacteria.
Key Product Specifications & Dosing Forms
| Feature | Specification |
| Active Ingredient | Pefloxacin mesylate |
| Pharmacological Class | Second-generation Fluoroquinolone Antibiotic |
| Available Formulations | Film-coated tablets, IV infusion solution |
| Common Strengths | 400 mg tablets; 400 mg/5 mL ampoules for infusion |
| Administration | Take orally twice daily with meals to avoid gastric irritation. Maintain high fluid intake during therapy |
Critical Safety Guidelines & Precautions
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Tendonitis & Tendon Rupture Risk: Pefloxacin carries a particularly high risk of tendonitis and Achilles tendon rupture among fluoroquinolones. Treatment must be discontinued immediately at the first sign of tendon pain or inflammation.
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Phototoxicity Warning: Peflotab causes marked photosensitivity. Patients should completely avoid exposure to direct sunlight, sunlamps, and UV radiation during treatment and for at least 4 days after stopping therapy.
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Chelation Interactions: Do not take Peflotab concurrently with antacids containing aluminum, magnesium, or calcium, iron supplements, or zinc multivitamins, as they severely reduce drug absorption. Separate administration by at least 2 hours before or 4 hours after.
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Age Limit & Pregnancy: Contraindicated in children and adolescents during the growth period (under 18 years), pregnant women, and nursing mothers due to potential cartilage damage in growing joints.
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