Ornilox

Ornilox is a broad-spectrum, dual-action combination anti-infective medication containing ofloxacin and ornidazole. It is formulated to eradicate polymicrobial infections by targeting aerobic bacteria, anaerobic bacteria, and protozoal parasites simultaneously:

• Ofloxacin (200 mg): A second-generation fluoroquinolone antibiotic that inhibits bacterial DNA gyrase and topoisomerase IV, effectively killing Gram-negative and Gram-positive aerobic bacteria.

• Ornidazole (500 mg): A nitroimidazole antiprotozoal and anaerobic antibacterial agent that damages DNA chains in protozoa and anaerobic bacteria, preventing them from multiplying.

Primary Medical Indications

Ornilox is indicated for adult patients suffering from acute or mixed bacterial-protozoal infections, including:

• Gastrointestinal & Diarrheal Illnesses: Acute amebic dysentery, bacillary dysentery, and severe infectious diarrhea/gastroenteritis caused by mixed bacterial and protozoal pathogens.

• Gynecological & Pelvic Infections: Pelvic Inflammatory Disease (PID), endometritis, vaginitis, and mixed genital tract infections (such as trichomoniasis combined with bacterial vaginosis).

• Urinary Tract & Surgical Infections: Complicated urinary tract infections, post-surgical abdominal infections, and intra-abdominal abscesses involving anaerobic pathogens.

• Dental & Oral Infections: Severe periodontitis, acute necrotizing ulcerative gingivitis (ANUG), and deep dental abscesses.

Key Product Specifications & Dosing Forms

Critical Safety Guidelines & Precautions

• Alcohol Warning: Patients should avoid alcohol during treatment and for at least 48 hours after stopping Ornilox, as nitroimidazoles like ornidazole can induce nausea, flushing, rapid heartbeat, and abdominal cramps.

• Tendonitis & CNS Precautions: Ofloxacin carries warnings for tendonitis, tendon rupture (especially the Achilles tendon), peripheral neuropathy, and potential central nervous system stimulation.

• Chelation & Absorption: Do not take Ornilox simultaneously with antacids containing aluminum or magnesium, iron supplements, zinc multivitamins, or calcium-rich products, as they impair ofloxacin absorption. Separate dosing by at least 2 hours.

• Pregnancy & Lactation: Contraindicated during the first trimester of pregnancy and in nursing mothers unless explicitly directed by a healthcare professional.